Welcome back to Humor Nation. The TVD Universe and Teen Wolf Universe are entirely different even though they share numerous similarities. While both shows consist of the werewolf species, but the powers, abilities, strengths and weaknesses of this species in both the shows are entirely different. An hypothetical argument would be who would win between the Original Hybrid Klaus Mikaelson and the true Alpha Scott McCall. Both of them have powerful abilities of a werewolf. While Klaus is a part Original Vampire which augments his werewolf nature. Also, if you compare the amount of experience these two have then Klaus would outweigh Scott easily. With a thousand-year experience, he has faced numerous vampires, werewolves, witches, ghosts, and all sorts of creatures and defeated them.
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Not just that, he had been daggered, impaled through his heart and yet he kept fighting. If you remember the fight between him and Tyler Lockwood in Season 1 where Tyler stakes through his chest, but he still defeated him. The amount of Klaus’ strength can be understood from the fact that he single handedly defeated an army of vampires of Marcel. There was only person whom Klaus Mikaelson truly feared, it was his father Mikael, but he took him down easily too. All this goes to show that the Original Hybrid could easily defeat the Teen Wolf hero in a one-to-one fight.
Scott McCall is a true Alpha, he managed to defeat the void Stiles, bested the Alpha Pack. He defeated Peter Hale, Deucalion, and numerous others. With his leadership quality and ability to work amazingly with a group of people, the McCall pack together proved to be overwhelming to the villains. If Scott works with the gang then they could even take down the mighty Klaus.
Klaus have been bested by the Mystic Falls Gang which consisted of humans and the vampires who were inferior to them. But they brought the Hybrid to his knees. The same Mystic Falls Gang managed to kill two Originals, brothers of Klaus, with ease. This just goes to show that McCall pack which comprises of a banshee, a hunter, beta wolves, a Kitsune, and an alpha would do more damage to Klaus Mikaelson. He has proven to be reckless and overconfident, often underestimating his foes and paying heavily.