Welcome back to Humor Nation. Two of the most epic shows that CW has ever produced are Vampire Diaries and Supernatural. Both of the shows played a major role in making CW one of the popular TV Networks in the world. These shows appealed to the younger audiences through fantasy and drama, a formula that would become the success recipe for the CW. The popularity of these shows resulted in an immense fanbase which is still active on the Internet, long after the shows have concluded. You could see the fans writing fan fiction involving the characters from both shows such as Winchesters/Salvatore, Stefan Salvatore/Sam Winchester.
But one of the biggest regrets the Network and the fans will have is to never a crossover between these two amazing shows. Both the shows shared numerous similar elements, both featured a pair of brothers associated with the Supernatural world. In TVD, the brothers are vampires whereas the Winchesters in Supernatural are hunters who hunt vampires. So it would have been amazing to see how the crossover would have gone.
While Supernatural lasted for 15 long seasons, The Vampire Diaries ran for 8 seasons. Despite their similarities, there are numerous differences between the two shows. One of the major differences is that Supernatural always placed the focus on Sam and Dean Winchester. Yes, the brothers were the centerpiece of every storyline while the supporting characters were given less screen time. Whereas if you look at the Vampire Diaries, the central characters had their moments throughout the eight seasons, but the supporting and new characters were also given a moment to shine. Take a look at the Originals arc, with the arrival of the Mikaelsons, the entire focus shifted on them. In a few episodes, Elijah and Klaus got more screen time than the Salvatores.
One of the major flaws or strengths of Vampire Diaries was its teen drama tropes. Ever since the show started, the entire atmosphere and the storytelling was teen centric style. There were numerous romances, heartbreaks, and teenage stuff. Whereas Supernatural never placed much emphasis on the romantic relationships which worked quite well for it. Even if you look at the action and fight scenes, Supernatural comparatively did a superior job.